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An absorption screen was performed in 10 chronic alcoholic patients within a few days of admission due to an acute alcoholic episode. Impaired absorption of d-Xylose was noted in three patients and low leucocyte ascorbic acid and serum folate levels in five. No abnormality was detected in jejunal histology. The absorption of water and electrolytes from the jejunum was studied in these patients using a triple-lumen tube perfusion system. The mean rate of absorption of water in the alcoholic subjects (50-0 +/- 2-3 ml/h) was significantly lower (P less than 0-001) than the mean value in 14 healthy control subjects (205 +/- 15-9 ml/h). A significant reduction of Na+ and Cl-absorption was also demonstrated in the alcoholic subjects. These results indicate that patients with acute-on-chronic alcoholism may have a function impairment of water and electrolyte absorption from the jejunum. This may, in part, account for some of the nutritional deficiencies in such patients and for symptoms such as diarrhoea which may be present.
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
January 1963,
The Scientific basis of medicine annual reviews,
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
March 1959,
Nordisk medicin,
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
June 1992,
Gastroenterology,
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
January 1971,
Scandinavian journal of gastroenterology. Supplement,
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
May 1958,
The Journal of pharmacology and experimental therapeutics,
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
October 1968,
Diabetes,
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
November 1975,
Pediatric clinics of North America,
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
January 1991,
Scandinavian journal of gastroenterology,
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
April 1963,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
N Krasner, and
K M Cochran, and
R I Russell, and
H A Carmichael, and
G G Thompson
April 1976,
Journal of dairy science,
