-transparent.png){kind=logo}
Acetylcholine (ACh)-induced vasodilation is mainly due to endothelium-derived nitric oxide (EDNO) and hyperpolarizing factor (EDHF). To explore the mechanisms underlying attenuated endothelium-dependent vasodilation in hypertensive arteries, we measured the EDNO released from isolated kidneys of spontaneously hypertensive rats (SHR) using a sensitive chemiluminescence assay system of NO. ACh-induced renal vasodilation was significantly smaller in SHR than in the normotensive control, Wistar-Kyoto rats (WKY). However, ACh-induced NO release did not differ between SHR and WKY (10(-7) M: SHR +37 +/- 2 [SE] vs. WKY +32 +/- 4 fmol/min/g kidney). Perfusion with a 20 mEq/L high-K+ buffer, which is reported to inhibit action of EDHF, significantly reduced ACh-induced vasorelaxation in WKY but not in SHR, resulting in identical renal perfusion pressure in SHR and wKY under these conditions. These results indicate that attenuated ACh-induced vasorelaxation in the SHR kidney may be attributed to a decrease in EDHF rather than that in EDNO.
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
October 1991,
American journal of obstetrics and gynecology,
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
December 1993,
Clinical and experimental pharmacology & physiology,
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
December 1995,
Clinical and experimental pharmacology & physiology. Supplement,
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
September 1993,
The American journal of physiology,
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
March 1993,
Changgeng yi xue za zhi,
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
May 1991,
Clinical science (London, England : 1979),
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
June 2006,
Vascular pharmacology,
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
March 1993,
European journal of pharmacology,
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
October 1989,
American journal of hypertension,
H Hayakawa, and
Y Hirata, and
E Suzuki, and
M Kakoki, and
K Kikuchi, and
T Nagano, and
M Hirobe, and
M Omata
February 1999,
British journal of pharmacology,
