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The administration of ATP-MgCl2 may be of benefit in the treatment of shock by improving cellular metabolic function during resuscitation. Prior studies have reported data from hemorrhage models in which heparinized shed blood is returned both during shock and in resuscitation. The purpose of this study was to test the effects of ATP-MgCl2 therapy upon blood pressure and survival in an animal model of hemorrhagic shock utilizing crystalloid (Lactated Ringer's) resuscitation. Adult male Sprague-Dawley rats (340-360 g) were bled 27 cc/kg and maintained in shock for 45 min. At the end of the shock period, animals were resuscitated with crystalloid at twice the original hemorrhage volume. A blinded three-arm study was conducted and animals were assigned to receive either Lactated Ringer's (LR) with placebo, LR with MgCl2, or LR with ATP-MgCl2. Blood pressure was monitored throughout the procedure and survival time was noted. Post-resuscitation MAP was increased in animals treated with ATP-MgCl2. ATP-MgCl2 added to resuscitation significantly improved 72-h survival over that of control (LR) animals, and animals treated with MgCl2 alone.
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
October 1995,
The American surgeon,
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
April 1995,
The American journal of physiology,
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
January 1983,
Circulatory shock,
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
January 2008,
Surgery today,
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
March 1985,
Surgery, gynecology & obstetrics,
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
January 1980,
Advances in shock research,
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
November 2014,
Shock (Augusta, Ga.),
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
May 1993,
The American journal of physiology,
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
January 1979,
Current surgery,
A Zambon, and
K Waxman, and
K Daughters, and
L Eloi
April 1996,
Resuscitation,
