Biomaterial Database

Effects of buthionine sulfoximine (BSO) on mercury distribution after Hg(o) exposure. 1995

C Y Kim, and C Watanabe, and H Satoh

Department of Environmental Health Sciences, Tohoku University School of Medicine, Sendai, Japan.

Effects of buthionine sulfoximine (BSO), a glutathione (GSH) depletor, on mercury (Hg) distribution were studied after mercury vapor (Hg(o)) exposure (3.2 mg/m3) in mice. BSO (1.6 g/kg, i.p.) significantly decreased the GSH levels in the liver, kidney and lung. Pretreatment with BSO increased Hg concentrations in the lung, liver and plasma, but decreased Hg concentration in the kidney. These findings indicate that GSH functions as a determinant in the changes of Hg distribution after Hg(o) exposure. Possible causes of the alterations in Hg distribution are discussed, including the anticipated enhancement in the Hg(o) oxidation process in the tissues with decreased GSH levels as well as the transportation of Hg2+ derived from oxidation of Hg(o). Concentrations of thiobarbituric acid reactive substances (TBARS) were determined as an indicator of oxidative damage, but the increase in TBARS was not detected in any tissue examined.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008628	Mercury	A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
D008717	Methionine Sulfoximine		Sulfoximine, Methionine
D008813	Mice, Inbred ICR	An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER.	Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D004347	Drug Interactions	The action of a drug that may affect the activity, metabolism, or toxicity of another drug.	Drug Interaction,Interaction, Drug,Interactions, Drug
D005721	Glutamate-Cysteine Ligase	One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.	gamma-Glutamyl-Cysteine Synthetase,Glutamylcysteine Synthetase,Glutamate Cysteine Ligase,Ligase, Glutamate-Cysteine,Synthetase, Glutamylcysteine,Synthetase, gamma-Glutamyl-Cysteine,gamma Glutamyl Cysteine Synthetase
D005978	Glutathione	A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.	Reduced Glutathione,gamma-L-Glu-L-Cys-Gly,gamma-L-Glutamyl-L-Cysteinylglycine,Glutathione, Reduced,gamma L Glu L Cys Gly,gamma L Glutamyl L Cysteinylglycine
D000704	Analysis of Variance	A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.	ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015227	Lipid Peroxidation	Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.	Lipid Peroxidations,Peroxidation, Lipid,Peroxidations, Lipid