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The in vitro and in vivo antitumor activity between DNL and autologous LAK cells was compared. The results showed that DNL cells activated in vitro by rIL-2 exhibited higher cytotoxicity to Tca 8113 cells than the same patient's LAK cells (75% and 36%, respectively). According to Winn's method, the inhibition rates of subcutaneously transplanted Tca cells in mice were 74% and 42% respectively. There was significantly difference in the antitumor activity in vitro and in vivo between two groups (P < 0.05), indicating that DNL cells which are more available are more practicable for adoptive immunotherapy.
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