-transparent.png){kind=logo}
Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group. EORTC Genito-Urinary Tract Cancer Cooperative Group. 1995
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
Free University Hospital, Department of Urology, Amsterdam, The Netherlands.
This double-blind randomised phase III trial was designed to assess the effect of pyridoxine administration on the recurrence of Ta and T1 transitional cell tumours of the bladder. The trial accrued 291 patients and showed no significant difference between the pyridoxine and placebo treatment groups with respect to the time to first recurrence or the recurrence rate. Adjustment for the main prognostic factors, namely the recurrence rate prior to entry, the number of tumours at entry, the G grade and the levels of the tryptophan metabolites kynurenine plus acetyl kynurenine at entry do not change the overall conclusions.
Related Publications
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
April 1999,
European urology,
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
September 1985,
European journal of cancer & clinical oncology,
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
January 1988,
Progress in clinical and biological research,
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
January 1998,
European urology,
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
April 1983,
European journal of cancer & clinical oncology,
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
May 1996,
Acta urologica Belgica,
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
October 1984,
European journal of cancer & clinical oncology,
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
August 1989,
European journal of cancer & clinical oncology,
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
December 1989,
European journal of cancer & clinical oncology,
D W Newling, and
M R Robinson, and
P H Smith, and
D Byar, and
R Lockwood, and
I Stevens, and
M De Pauw, and
R Sylvester
September 1998,
Urology,
