-transparent.png){kind=logo}
We investigated the effects of moricizine HCl, a type Ic anti-arrhythmic agent, on heart rate variability. Decreased heart rate variability is a risk factor for mortality in post-MI and other patient populations, and some antiarrhythmic drugs decrease heart rate variability. Normal volunteers (10 M, 11 F, age 19-39 years) received blinded placebo and moricizine HCl at 200 mg twice daily for 5 days. On day 4, a 24-h ECG was obtained, and time and frequency domain measures of heart rate variability based on normal-to-normal intervals were computed. Moricizine decreased both time and frequency domain measures of heart rate variability. Significant reductions were seen for SDNNIDX (the average S.D. for N-Ns for each 5-min interval in ms) and pNN50 (the proportion of successive N-N differences > 50 ms in percent) in the time domain, and very low (0.0033-0.04 Hz), low (0.04-0.15 Hz) and high (0.15-0.4 Hz) frequency power. Similar patterns of change in heart rate variability were seen when data for daytime and nighttime periods were analyzed separately. rMSSD (the root mean square successive difference of N-N intervals in ms), pNN50 and high frequency power are primarily indices of parasympathetic tone. SDNNIDX, and very low and low frequency power reflect both sympathetic and parasympathetic tone and longer term variability. Thus, moricizine decreases both vagal tone and longer term components of heart rate variability. This decrease produced by moricizine is similar to that reported with other type 1 antiarrhythmics.
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
November 1997,
The American journal of cardiology,
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
March 1990,
The American journal of cardiology,
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
May 1989,
The American journal of cardiology,
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
June 1995,
The American journal of physiology,
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
June 2007,
Journal of manipulative and physiological therapeutics,
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
September 1991,
The American journal of cardiology,
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
January 2014,
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
March 1996,
International journal of cardiology,
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
January 2021,
PloS one,
P K Stein, and
J N Rottman, and
T Kuru, and
R E Kleiger
January 2011,
Journal of exposure science & environmental epidemiology,
