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We compared neurosensorial visual function by psychophysical tests (macular recovery time and contrast sensitivity) in two well matched groups of young Type 1 (insulin-dependent) diabetic patients with micro- and normoalbuminuria, respectively. The patients had normal visual acuity (> or = 1.0) and either no retinopathy or non-proliferative retinopathy. Thirty patients with microalbuminuria (albumin excretion > or = 15 micrograms/min in a least two out of three timed overnight urine samples) were matched (age, diabetes duration, mean one-year HbA1c, gender) with normoalbuminuric (n = 27) patients. Retinopathy (50 degree colour fundus photography) was assessed by counting microaneurysms and hemorrhages as 'red spots'. Contrast sensitivity was examined for the spatial frequencies of 1.5, 3, 6, 12 and 18 cycles per degree (cpd). Macular recovery time (nyctometry) refers to the time-related (2 min) ability of the retina to regain visual acuity following exposure to bright light (photostress). Contrast sensitivity score was reduced in patients with microalbuminuria compared to those without; 18 cpd (mean and 95% confidence intervals): [4.2 (3.8-4.7) vs 5.0 (4.6-5.4), p = 0.03]. Macular recovery performance was not significantly reduced: [21.0 arbitrary units (17.5-24.6) vs 26.0 (22.6-30.7), p = 0.12]. We conclude that impaired contrast sensitivity independent of background retinopathy is shown in a group of young Type 1 (insulin-dependent) diabetic patients with low-grade microalbuminuria compared to a group of patients with normoalbuminuria.
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
June 1993,
Diabetologia,
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
June 1994,
Arteriosclerosis and thrombosis : a journal of vascular biology,
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
April 1992,
Kidney international,
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
October 1993,
Diabetologia,
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
August 1990,
Diabetologia,
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
November 1992,
Diabetologia,
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
October 1993,
Lancet (London, England),
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
January 1989,
Acta diabetologica latina,
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
March 2008,
Diabetic medicine : a journal of the British Diabetic Association,
H J Bangstad, and
O Brinchmann-Hansen, and
S Hultgren, and
K Dahl-Jørgensen, and
K F Hanssen
September 1989,
Diabetologia,
