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Since oxidized LDL may play a role in the genesis of atheroma, which is the primary complication of non-insulin-dependent diabetes mellitus (NIDDM), we investigated whether the LDL of diabetic patients were more prone to oxidation than those of healthy controls. We therefore studied the susceptibility of LDL to oxidation by phenylhydrazine (LDL-PO) in NIDDM patients with or without macroangiopathy, and in controls. Results showed that the LDL of patients with macroangiopathy (n = 50) were more susceptible to oxidation than those of both NIDDM patients without vascular complications (n = 50) and controls (n = 50). In diabetic patients, there was a positive correlation between LDL-PO and the following parameters: total cholesterol, triglycerides, LDL cholesterol, apolipoprotein B. In contrast, there was no correlation between LDL-PO and the parameters of glycemic control (fasting glucose, HbAlc). After analyzing the composition of LDL, it appeared that LDL-PO values in diabetic patients were positively correlated with those of all LDL constituents. The increase in LDL-PO observed in the group of NIDDM patients with macroangiopathy could be a consequence of an increase in the LDL triglyceride content in these patients.
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
January 1991,
Diabete & metabolisme,
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
January 1994,
Diabetes research (Edinburgh, Scotland),
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
July 1997,
Arteriosclerosis, thrombosis, and vascular biology,
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
December 1995,
The American journal of clinical nutrition,
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
November 1998,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
January 1988,
Revista paulista de medicina,
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
October 1987,
British medical journal (Clinical research ed.),
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
December 1987,
British medical journal (Clinical research ed.),
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
January 1997,
Biofizika,
G Gallou, and
A Ruelland, and
L Campion, and
H Allannic, and
B Legras, and
L Cloarec
December 1997,
Current opinion in lipidology,
