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Intraosseous lipomas are considered to be among the rarest primary benign bone tumors. Lipoma developing in bone frequently presents evolutional changes, which in association with the lack of clinical information and the radiographic appearance of the bone lesion could be the main reasons for misinterpretation of the histological picture. We present three cases of intraosseous lipoma which developed in male patients aged 23, 34 and 35 years, involving the tibia (n = 2) and calcaneus (n = 1). The histologic pattern of all tumors was that of mature adipose tissue. The diagnosis was made by correlating the clinical and radiographic findings to those of light microscopy.
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