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This study was designed to investigate the effect of topical ketanserin, a selective S2-serotonin antagonist, on wound healing and contraction in surgical wounds allowed to heal by second intention. Thirty-five patients applied placebo or 2% ketanserin gel, double-blind, to head and neck wounds resulting from skin tumour excision, and allowed to heal by second intention. Healing rate was assessed from the change in the square root of wound area, and in 11 patients wound contraction was assessed by the change in the area delineated by wound margin tattoo marks. There were no significant differences in any of the measurements made between the ketanserin- and placebo gel-treated patients. Wound healing was significantly faster in large wounds. Wound contraction was greatest in the early stages of healing, and accounted for 53% of healing. We conclude that, on normally vascularized skin, ketanserin gel has no significant effect on wound healing rate.
C M Lawrence, and
J N Matthews, and
N H Cox
January 1980,
Clinical bulletin,
C M Lawrence, and
J N Matthews, and
N H Cox
January 1957,
Vestnik rentgenologii i radiologii,
C M Lawrence, and
J N Matthews, and
N H Cox
January 1963,
Polski przeglad chirurgiczny,
C M Lawrence, and
J N Matthews, and
N H Cox
January 1977,
Roczniki Akademii Medycznej im. Juliana Marchlewskiego w Bialymstoku,
C M Lawrence, and
J N Matthews, and
N H Cox
January 2002,
Journal of endodontics,
C M Lawrence, and
J N Matthews, and
N H Cox
February 2004,
The Canadian veterinary journal = La revue veterinaire canadienne,
C M Lawrence, and
J N Matthews, and
N H Cox
January 1962,
Frankfurter Zeitschrift fur Pathologie,
C M Lawrence, and
J N Matthews, and
N H Cox
August 2015,
The British journal of dermatology,
C M Lawrence, and
J N Matthews, and
N H Cox
February 1958,
The Bulletin of the Tulane Medical Faculty,
C M Lawrence, and
J N Matthews, and
N H Cox
January 1953,
Acta chirurgica Patavina,
