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Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or levothyroxine therapy (study 2). The SHBG levels are increased in hyper- and decreased in hypothyroid patients, whereas CBG levels are increased in hypo- and decreased in hyperthyroid patients. The SHBG levels are higher in women than in men with similar thyroid status. Plasma SHBG levels are correlated positively whereas CBG levels are correlated negatively with free thyroid hormone concentrations in men as well as women. In hypothyroid patients, SHBG concentrations increased (p < 0.01) and CBG concentrations decreased (p < 0.01) during levothyroxine treatment. In hyperthyroid patients, SHBG concentrations decreased (p < 0.01) and CBG concentrations increased (p < 0.01) during antithyroid treatment. The SHBG and CBG concentrations in treated hypo- and hyperthyroid patients were not significantly different from those of euthyroid controls. Our data indicate that SHBG and CBG levels depend on thyroid status. Corticosteroid-binding globulin is an index of thyroid hormone action at the liver level whose changes are opposite to those of SHBG in hyper- and hypothyroidism.
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
January 1988,
Annals of the New York Academy of Sciences,
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
March 2014,
Steroids,
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
June 2006,
The Journal of clinical endocrinology and metabolism,
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
February 1990,
Endocrine reviews,
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
January 1987,
Hormone research,
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
October 1994,
Cancer research,
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
January 2000,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
February 1985,
American journal of obstetrics and gynecology,
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
September 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
S C Dumoulin, and
B P Perret, and
A P Bennet, and
P J Caron
November 1986,
Nihon Sanka Fujinka Gakkai zasshi,
