Biomaterial Database

Polymorphic acetylation of nitrazepam. 1976

A K Karim, and D A Evans

Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009567	Nitrazepam	A benzodiazepine derivative used as an anticonvulsant and hypnotic.	Nitrodiazepam,Alodorm,Dormalon,Dormo-Puren,Eatan,Imadorm,Imeson,Mogadon,Nitrazadon,Nitrazep,Nitrazepam AL,Nitrazepam-Neuraxpharm,Novanox,Radedorm,Remnos,Rhoxal-Nitrazepam,Serenade,Somnite,Nitrazepam Neuraxpharm,Rhoxal Nitrazepam
D010641	Phenotype	The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.	Phenotypes
D011110	Polymorphism, Genetic	The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.	Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D013418	Sulfamethazine	A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.	Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-,Sulfadimidine,Sulphamethazine,Sulfadimezine,Sulphamezathine