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A strain of Plasmodium falciparum, transmitted in Irian Jaya (Indonesian New Guinea) was isolated in 1974 and sent to the University of Maryland for characterization in nonimmune volunteers. At Maryland the Indonesia (Whit.) strain, as it has been designated, was transmitted to colonized Anopheles stephensi. Prophylactically, it was not suppressed by proguanil hydrochloride 100 mg. daily. Curatively, parasitaemia was not cleared by treatment with 1-5 g. (base) in three days of chloroquine or amodiaquine (RII responses), nor by treatment with 150 mg. of pyrimethamine in three days (RIII), and some resistance was also shown to quinine. A single dose of 1-5 g. of mefloquine (WR 142,490) produced radical cure in the two patients treated with this new 4-quinolinemethanol compound.
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
September 1978,
Papua and New Guinea medical journal,
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
March 1975,
Annals of tropical medicine and parasitology,
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
January 1988,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
August 1976,
The Medical journal of Australia,
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
November 1976,
The Medical journal of Australia,
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
January 1977,
The Medical journal of Australia,
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
September 1980,
Papua and New Guinea medical journal,
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
January 1991,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
July 1978,
The Medical journal of Australia,
D F Clyde, and
V C McCarthy, and
R M Miller, and
R B Hornick
March 1984,
Tropical and geographical medicine,
