-transparent.png){kind=logo}
Corticotropin-releasing factor (CRF) mediates many critical aspects of the physiological response to stress. These effects are elicited by binding to specific high-affinity receptors, which are coupled to guanine nucleotide stimulatory factor (Gs)-response pathways. Recently, a gene encoding a receptor for CRF, expressed in pituitary and the central nervous system (PC-CRF receptor), was isolated and characterized. Here we report the identification and characterization of a second, distinct CRF receptor that is expressed primarily in heart and skeletal muscle and exhibits a specific ligand preference and antagonist sensitivity compared with the PC-CRF receptor. We refer to this second receptor as the heart/muscle (HM)-CRF receptor.
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
January 2005,
Journal of medicinal chemistry,
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
July 2004,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
August 1997,
Molecular and cellular endocrinology,
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
December 1993,
Neuron,
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
July 1982,
Regulatory peptides,
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
July 1985,
The American journal of physiology,
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
March 1995,
Proceedings of the National Academy of Sciences of the United States of America,
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
November 1983,
Pharmacology, biochemistry, and behavior,
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
September 2002,
The Journal of biological chemistry,
T Kishimoto, and
R V Pearse, and
C R Lin, and
M G Rosenfeld
January 1987,
Peptides,
