Biomaterial Database

[G1 cyclin degradation and cell differentiation in Saccharomyces cerevisiae]. 1995

Y Barral, and C Mann

Service de biochimie et génétique moléculaire, Commissariat à l'énergie atomique, Gif-sur-Yvette, France.

The baker's yeast Saccharomyces cerevisiae can undergo pseudohyphal differentiation upon limited starvation for nitrogen. This differentiation is characterized by a hyperpolarized cell growth that gives rise to elongated cells. These elongated cells can form chains that penetrate an agar surface. The study of the grr1 mutant, affected in the degradation of the G1 cyclins, showed that the stabilization of Cln1 and Cln2 leads to a similar hyperpolarized cell growth. We suggest that G1 cyclin stability is a key element controlling cellular morphogenesis. Examination of G1 cyclin turnover during pseudohyphal growth strongly supports this hypothesis. Saccharomyces cerevisiae is thus an interesting model for studying the interconnections between cell cycle control and cellular differentiation.

UI	MeSH Term	Description	Entries
D009154	Mutation	Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.	Mutations
D002454	Cell Differentiation	Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.	Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D003470	Culture Media	Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.	Media, Culture
D012441	Saccharomyces cerevisiae	A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.	Baker's Yeast,Brewer's Yeast,Candida robusta,S. cerevisiae,Saccharomyces capensis,Saccharomyces italicus,Saccharomyces oviformis,Saccharomyces uvarum var. melibiosus,Yeast, Baker's,Yeast, Brewer's,Baker Yeast,S cerevisiae,Baker's Yeasts,Yeast, Baker
D016213	Cyclins	A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.	Cyclin
D056746	Cyclin G	A cyclin subtype that is found associated with CYCLIN-DEPENDENT KINASE 5; cyclin G associated kinase, and PROTEIN PHOSPHATASE 2.