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Stobadine (STB), a cardioprotective drug, was investigated for its placental transfer in rabbits on the 20th and 27th day of gestation. The concentration of 3H-STB and its metabolites was determined in maternal and foetal plasma and organs at 0.5; 1; 2; and 6 h after the oral administration of 5 mg/kg STB. The third and fifth order linear models were selected as the optimal models of the fate of STB in the maternal plasma at the 20th and 27th day of gestation, respectively. The high order of the latter model indicated recirculation of STB in the maternal body at the last stage of gestation. The concentrations of STB and its metabolites in the uterus were found to be higher at mid- than late-pregnancy. At the 27th day of pregnancy the concentration of STB and its metabolites were higher in all foetal organs than on the concentrations at the 20th day of pregnancy, indicating active placental barrier function in mid-pregnancy.
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
March 1978,
Biulleten' eksperimental'noi biologii i meditsiny,
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
January 1999,
Life sciences,
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
December 2020,
Drug metabolism and disposition: the biological fate of chemicals,
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
January 2010,
Diabetes care,
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
August 1963,
American journal of obstetrics and gynecology,
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
January 1998,
European journal of obstetrics, gynecology, and reproductive biology,
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
April 2024,
Pharmaceutical research,
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
December 2013,
Drug metabolism and disposition: the biological fate of chemicals,
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
November 1995,
Mutagenesis,
E Ujházy, and
V Faberová, and
M Dubovický, and
M Zemánek, and
J Jansák, and
L Dedík, and
M Durisová
September 1993,
Investigative radiology,
