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There are nearly 50 alleles at the highly polymorphic HLA-A class I locus that fall into six distinct families. To determine the allelic repertoire and the mechanism of generation of diversity of the A locus in primates we have analyzed A locus alleles from 28 apparently unrelated chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). We have, therefore, compared the sequences of 19 HLA-A homologues from chimpanzees and bonobos to 42 HLA-A sequences. HLA-A homologues were well preserved in chimpanzees and bonobos with very few new substitutions present in the A locus alleles of both species of chimpanzee. Surprisingly, all chimpanzees and bonobos expressed A locus alleles related to only one of the six families of human HLA-A alleles. This suggests that the common ancestor of these two species either passed through a genetic bottleneck or that selection has favored the maintenance of the HLA-A1, -A3, -A11 family in chimpanzees.
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
November 1993,
Journal of immunology (Baltimore, Md. : 1950),
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
June 2001,
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics,
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
December 1991,
The Journal of experimental medicine,
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
June 1998,
Tissue antigens,
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
April 2002,
Annals of the New York Academy of Sciences,
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
September 1988,
The EMBO journal,
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
June 2004,
Immunogenetics,
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
October 2001,
Journal of immunology (Baltimore, Md. : 1950),
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
September 1993,
Human molecular genetics,
S N McAdam, and
J E Boyson, and
X Liu, and
T L Garber, and
A L Hughes, and
R E Bontrop, and
D I Watkins
January 2003,
Methods in molecular biology (Clifton, N.J.),
