-transparent.png){kind=logo}
Fibroblasts as efficient antigen-presenting cells in lymphoid organs. 1995
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
Institute of Experimental Immunology, University of Zürich, Switzerland.
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
Related Publications
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
January 2016,
Frontiers in immunology,
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
January 2017,
Theranostics,
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
December 2010,
Nature reviews. Immunology,
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
June 2018,
Immunity, inflammation and disease,
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
December 2013,
Investigacion clinica,
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
December 2021,
Nature,
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
March 2001,
The Journal of clinical investigation,
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
May 2016,
Immunological reviews,
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
July 1980,
The Journal of investigative dermatology,
T M Kündig, and
M F Bachmann, and
C DiPaolo, and
J J Simard, and
M Battegay, and
H Lother, and
A Gessner, and
K Kühlcke, and
P S Ohashi, and
H Hengartner
July 1994,
Immunology today,
