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Talampicillin is a thiazolide carboxylic ester of ampicillin and is hydrolysed in the intestinal mucosa to release free ampicillin. The mean peak serum concentration of ampicillin occurred one hour after a dose of talampicillin and was about twice that attained by an equivalent dose of ampicillin. The presence of food in the stomach reduced and delayed the peak blood levels but did not affect the total amount of antibiotic absorbed or the urinary recovery. Talampicillin had less effect on the faecal flora in volunteers than ampicillin, and no overgrowth with Candida spp or Staphylococcus aureus was seen. Thirty-eight out of 47 urinary infections were eradicated by a seven-day course of talampicillin.
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
July 1976,
British medical journal,
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
July 1976,
British medical journal,
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
August 1976,
British medical journal,
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
August 1977,
Drug and therapeutics bulletin,
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
April 1971,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
November 1975,
Arzneimittel-Forschung,
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
January 1974,
Deutsche medizinische Wochenschrift (1946),
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
April 1976,
The Practitioner,
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
June 1974,
Antimicrobial agents and chemotherapy,
D A Leigh, and
D S Reeves, and
K Simmons, and
A L Thomas, and
P J Wilkinson
October 1975,
The British journal of clinical practice,
