-transparent.png){kind=logo}
1. Venous blood concentrations of the branched-chain amino acids, valine, leucine and isoleucine, and urinary nitrogen excretion have been measured in sixteen adult males, from 2 h to 7 days after injury, and in four adults after elective skin grafts. 2. In the injured group the concentrations of these amino acids rose significantly 24 h after injury and had doubled at 4 days and remained high; in contrast the skin-graft patients showed no significant change. 3. In those injured patients with initial hyperketonaemia, defined as more than 0-2 mmo1/1, the increase in concentrations of branched-chain amino acids at the fourth and seventh days after injury was significantly less than in those with normoketonaemia, and was accompanied by lower urinary nitrogen excretion throughout the whole period. 4. It is suggested that the changes in the concentration of branched-chain amino acids after injury indicate decreased uptake by muscle or excessive release due to an imbalance between protein synthesis and protein catabolism in this tissue.
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
January 1982,
Diabetes,
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
February 2019,
Annual review of physiology,
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
January 1988,
Methods in enzymology,
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
January 2017,
Advances in biochemical engineering/biotechnology,
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
July 2000,
Journal of gastroenterology and hepatology,
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
January 1992,
Contributions to nephrology,
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
January 1984,
Nutrition and cancer,
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
February 1966,
Journal of biochemistry,
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
December 1997,
Minerva gastroenterologica e dietologica,
J H Wedge, and
R De Campos, and
A Kerr, and
R Smith, and
R Farrell, and
V Ilic, and
D H Williamson
January 2006,
The Journal of nutrition,
