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Electrolytic lesions placed in the median eminence of adult male rats are followed, in 7--10 days, by a significant decrease in pituitary FSH concentration. The intravenous injection of a hypothalamic extract prepared from normal animals induces, in 45 minutes, a significant increase in the amounts of FSH stored in the pituitary of median eminence-lesioned animals. The concentration of FSH in the pituitary of lesioned animals is also increased to normal by the intravenous injection of an extract prepared from the isolated hypothalamic island of animals previously submitted to a total "hypothalamic deafferentation", in spite of the fact that this does not contain any FSH-RF activity. It is suggested that the hypothalamus possesses separate humoral factors for the regulation of the release and of the synthesis of pituitary FSH.
M Motta, and
E L Daniels, and
L Martini
June 2012,
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M Motta, and
E L Daniels, and
L Martini
June 1974,
Acta endocrinologica,
M Motta, and
E L Daniels, and
L Martini
May 1971,
Endocrinology,
M Motta, and
E L Daniels, and
L Martini
November 1970,
Endocrinology,
M Motta, and
E L Daniels, and
L Martini
March 1968,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Motta, and
E L Daniels, and
L Martini
April 1976,
Endocrinology,
M Motta, and
E L Daniels, and
L Martini
April 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Motta, and
E L Daniels, and
L Martini
August 1982,
Acta endocrinologica,
M Motta, and
E L Daniels, and
L Martini
January 1970,
The Scientific basis of medicine annual reviews,
M Motta, and
E L Daniels, and
L Martini
January 2002,
Reproduction (Cambridge, England). Supplement,
