Biomaterial Database

Anticonvulsive effect of urethane on aminopyridine-induced epileptiform activity. 1995

G Heltovics, and B Boda, and M Szente

Department of Comparative Physiology, Attila József University, Szeged, Hungary.

The effects of urethane anaesthesia on the development and spread of ictal-like epileptiform activity induced by 3-aminopyridine, was investigated on the somatosensory cortex of rats. Under urethane anaesthesia in most animals only one abortive ictal period appeared with dose-dependent latency. Urethane completely abolished high frequency afterdischarges (5-10 Hz) and prevented the development of recurrent seizures in both primary and mirror foci. Urethane also eliminated ongoing epileptiform activity induced previously by 3-aminopyridine under nembutal anaesthesia. The antiepileptic effects of urethane on ictal-like activity may be the consequence of a presynaptic action through reduction of glutamate-mediated excitation together with a depressant effect on responsiveness of cortical neurones. The afterdischarges of high frequency could be essential to development and stabilization of repetitive tonic events in the neocortex.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004827	Epilepsy	A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)	Aura,Awakening Epilepsy,Seizure Disorder,Epilepsy, Cryptogenic,Auras,Cryptogenic Epilepsies,Cryptogenic Epilepsy,Epilepsies,Epilepsies, Cryptogenic,Epilepsy, Awakening,Seizure Disorders
D005260	Female		Females
D000631	Aminopyridines	Pyridines substituted in any position with an amino group. May be hydrogenated but must retain at least one double bond.	Aminopyridine
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013003	Somatosensory Cortex	Area of the parietal lobe concerned with receiving sensations such as movement, pain, pressure, position, temperature, touch, and vibration. It lies posterior to the central sulcus.	Brodmann Area 1,Brodmann Area 2,Brodmann Area 3,Brodmann Areas 1, 2, 3,Brodmann Areas 1, 2, and 3,Brodmann Areas 3, 1, 2,Brodmann Areas 3, 1, and 2,Brodmann's Area 1,Brodmann's Area 2,Brodmann's Area 3,Brodmann's Areas 1, 2, and 3,Brodmann's Areas 3, 1, and 2,Parietal-Opercular Cortex,Primary Somesthetic Area,S1 Cortex,S2 Cortex,SII Cortex,Anterior Parietal Cortex,Gyrus Postcentralis,Post Central Gyrus,Postcentral Gyrus,Primary Somatic Sensory Area,Primary Somatosensory Area,Primary Somatosensory Areas,Primary Somatosensory Cortex,SI Cortex,Second Somatic Sensory Area,Secondary Sensory Cortex,Secondary Somatosensory Area,Secondary Somatosensory Cortex,Area 1, Brodmann,Area 1, Brodmann's,Area 2, Brodmann,Area 2, Brodmann's,Area 3, Brodmann,Area 3, Brodmann's,Area, Primary Somatosensory,Area, Primary Somesthetic,Area, Secondary Somatosensory,Areas, Primary Somatosensory,Brodmanns Area 1,Brodmanns Area 2,Brodmanns Area 3,Cortex, Anterior Parietal,Cortex, Parietal-Opercular,Cortex, Primary Somatosensory,Cortex, S1,Cortex, S2,Cortex, SI,Cortex, SII,Cortex, Secondary Sensory,Cortex, Secondary Somatosensory,Cortex, Somatosensory,Gyrus, Post Central,Gyrus, Postcentral,Parietal Cortex, Anterior,Parietal Opercular Cortex,Parietal-Opercular Cortices,Primary Somatosensory Cortices,Primary Somesthetic Areas,S1 Cortices,S2 Cortices,SII Cortices,Secondary Somatosensory Areas,Sensory Cortex, Secondary,Somatosensory Area, Primary,Somatosensory Area, Secondary,Somatosensory Areas, Primary,Somatosensory Cortex, Primary,Somatosensory Cortex, Secondary,Somesthetic Area, Primary,Somesthetic Areas, Primary
D014520	Urethane	Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.	Ethyl Carbamate,Urethan,Carbamate, Ethyl
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus