BIOMAT Database Logo BIOMAT Database Logo

Alveolar fibrosis and capillary alteration in experimental pulmonary silicosis in rats. 1995

O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
Pathology and Clinical Research Laboratory, Nippon Medical School Second Hospital, Kawasaki-shi, Japan.

To analyze the evolution of fibrotic and vascular changes in pulmonary silicosis, ultrastructural and immunohistochemical studies were made of the lungs of rats given a single intratracheal injection of silica particles. Early lesions were characterized by accumulations of macrophages and neutrophils in alveolar lumina and interstitium and by damage to alveolar capillaries and epithelial cells. The intraluminal masses of inflammatory cells developed into granulomas and became associated with myofibroblasts that migrated from the interstitium through the damaged epithelial lining. Type II epithelial cells and bronchiolar cuboidal cells proliferated rapidly to line the intraluminal granulomas, incorporating them into the interstitium. This process mediated the transition from intraalveolar fibrosis to interstitial fibrosis. Vascular damage was repaired by proliferation and migration of endothelial cells. Some endothelial cells in alveolar capillaries expressed Factor VIII-related antigen at 2 wk after silica infusion. In normal animals, this feature was present in peribronchiolar but not in alveolar capillaries. Two patterns of endothelial cell migration were shown by staining for proliferating-cell nuclear antigen. The first pattern was characterized by endothelial cells that extended their cytoplasm over preexisting, denuded basement membranes and replaced necrotic cells in alveolar capillaries. At 4 mo after injury, some of these cells had developed fenestrations. The second pattern consisted of budlike sproutings that developed only in peribronchiolar connective tissue. These observations indicate that peribronchiolar vessels are sources for renewal of alveolar capillary endothelium as well as for neovascularization.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D008854 Microscopy, Electron Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen. Electron Microscopy
D011650 Pulmonary Alveoli Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place. Alveoli, Pulmonary,Alveolus, Pulmonary,Pulmonary Alveolus
D011658 Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. Alveolitis, Fibrosing,Idiopathic Diffuse Interstitial Pulmonary Fibrosis,Fibroses, Pulmonary,Fibrosis, Pulmonary,Pulmonary Fibroses,Alveolitides, Fibrosing,Fibrosing Alveolitides,Fibrosing Alveolitis
D004730 Endothelium, Vascular Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components. Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012829 Silicosis A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic. Silicoses
D014841 von Willebrand Factor A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor. Factor VIII-Related Antigen,Factor VIIIR-Ag,Factor VIIIR-RCo,Plasma Factor VIII Complex,Ristocetin Cofactor,Ristocetin-Willebrand Factor,von Willebrand Protein,Factor VIII Related Antigen,Factor VIIIR Ag,Factor VIIIR RCo,Ristocetin Willebrand Factor
D016676 Macrophages, Alveolar Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Alveolar Macrophages,Macrophages, Pulmonary,Pulmonary Macrophages,Macrophage, Pulmonary,Pulmonary Macrophage,Alveolar Macrophage,Macrophage, Alveolar

Related Publications

O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
Fenestration of alveolar capillary endothelium in experimental pulmonary fibrosis.
October 1969, Laboratory investigation; a journal of technical methods and pathology,
O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
Pulmonary fibrosis: bronchoalveolar cell types and impaired function of alveolar macrophages in experimental silicosis.
February 1982, Environmental research,
O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
[Pulmonary alveolar proteinosis in silicosis].
January 1979, Terapevticheskii arkhiv,
O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
[Alveolar surface forces and composition of the pulmonary surfactant in experimental silicosis].
January 1971, Internationales Archiv fur Arbeitsmedizin,
O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
[Endothelial metaplasia of the alveolar capillaries in experimental silicosis of rats].
March 1995, Nihon Kyobu Shikkan Gakkai zasshi,
O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
Pulmonary histopathology and alteration in cellular pattern of bronchoalveolar lavage fluid in experimental silicosis.
July 2000, Indian journal of experimental biology,
O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
Heterogeneity of alveolar macrophages in experimental silicosis.
July 1992, Environmental health perspectives,
O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
Pulmonary alveolar proteinosis: relationship to silicosis and pulmonary infection.
April 1980, Radiology,
O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
Enhanced pulmonary absorption of drugs in rats with experimental silicosis.
March 1976, Research communications in chemical pathology and pharmacology,
O Kawanami, and H X Jiang, and H Mochimaru, and H Yoneyama, and S Kudoh, and H Ohkuni, and H Ooami, and V J Ferrans
[Pulmonary capillary, alveolar epithelium and macrophage ultrastructure in germ-free rats].
November 1974, Biulleten' eksperimental'noi biologii i meditsiny,
Copied contents to your clipboard!