Biomaterial Database

The multifactorial etiology of autoimmune diseases. 1994

J F Bach

Immunologie Clinique, Hôpital Necker, Paris, France.

The etiology of autoimmune diseases remains a matter of debate. The respective roles of predisposition genes and environmental factors on the one hand, and the opposing effect of promoting and protective factors, on the other hand, are still ill-defined. A large amount of data recently obtained in either experimental models or in human diseases open new perspectives in the understanding of this etiology. We shall briefly review here some of these data.

UI	MeSH Term	Description	Entries
D004777	Environment	The external elements and conditions which surround, influence, and affect the life and development of an organism or population.	Environmental Impact,Environmental Impacts,Impact, Environmental,Impacts, Environmental,Environments
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001327	Autoimmune Diseases	Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	Autoimmune Disease,Disease, Autoimmune,Diseases, Autoimmune