[Effect of coronary artery bypass grafting on left ventricular diastolic function in coronary artery disease--an assessment using pulsed Doppler echocardiography]. 1995

R Higashita
Department of Cardiovascular Surgery, Tokyo Women's Medical College Daini Hospital, Japan.

To evaluate the effect of coronary artery bypass grafting (CABG) on left ventricular (LV) diastolic function in coronary artery disease (CAD), pulsed Doppler echocardiography was performed in the patients undergoing CABG between February 1991 and March 1993. The patients with non-sinus rhythm, more than 100 heart beats/min, aortic or mitral valvular disease, and perioperative myocardial infarction or left ventricular aneurysm were excluded from this study. CAD group consisted of 24 patients and Control group 17 normal subjects with no evidence of angina nor ischemic findings on electrocardiogram. No significant differences were found in heart rate, mean blood pressure, left atrial dimension and LV ejection fraction in two groups. Pulsed Doppler echocardiographic examinations showed that in comparison with Control group, E/A ratio was decreased (0.72 vs 0.89, p < 0.05) and IRT prolonged (115.9 vs 92.4, p < 0.05) in CAD group. These results indicated impaired diastolic function in CAD patients. In CAD group, echocardiographic study was performed 3 to 4 weeks after CABG. In 16 patients in whom heart rates at the pre- and the postoperative examinations were relatively identical, E/A ratio increased postoperatively from 0.66 to 0.96 (p < 0.001) and IRT and DHT shortened from 115.2 ms to 86.6 ms (p < 0.001) and from 96.3 ms to 82.4 ms (p < 0.05) respectively. In addition, DC increased from 2.04 cm/s2 to 3.02 cm/s2 (p < 0.005) postoperatively. The results indicated that CABG improved LV diastolic function in CAD patients. In summery, this study indicated that impaired LV diastolic filling was found in CAD patients and that CABG improved LV diastolic function in CAD patients.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003327 Coronary Disease An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. Coronary Heart Disease,Coronary Diseases,Coronary Heart Diseases,Disease, Coronary,Disease, Coronary Heart,Diseases, Coronary,Diseases, Coronary Heart,Heart Disease, Coronary,Heart Diseases, Coronary
D003971 Diastole Post-systolic relaxation of the HEART, especially the HEART VENTRICLES. Diastoles
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001026 Coronary Artery Bypass Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion. Aortocoronary Bypass,Bypass, Coronary Artery,Bypass Surgery, Coronary Artery,Coronary Artery Bypass Grafting,Coronary Artery Bypass Surgery,Aortocoronary Bypasses,Artery Bypass, Coronary,Artery Bypasses, Coronary,Bypass, Aortocoronary,Bypasses, Aortocoronary,Bypasses, Coronary Artery,Coronary Artery Bypasses
D016277 Ventricular Function, Left The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance. Left Ventricular Function,Function, Left Ventricular,Functions, Left Ventricular,Left Ventricular Functions,Ventricular Functions, Left
D018619 Echocardiography, Doppler, Pulsed Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return. Doppler Echocardiography, Pulsed,Echocardiography, Pulsed Doppler,Doppler Pulsed Echocardiography,Echocardiography, Doppler Pulsed,Pulsed Doppler Echocardiography,Pulsed Echocardiography, Doppler

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