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Incubation of cultured rat vascular smooth muscle cells with interleukin-1 beta caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide (NO), in time- and dose-dependent manners. Addition of ouabain to the culture further enhanced interleukin-1 beta-induced nitrite production. Similarly, interleukin-1 beta produced a significant increase in the cellular level of guanosine 3',5'-cyclic monophosphate, and the increase was significantly enhanced by coincubation with ouabain. The calcium ionophore ionomycin also significantly enhanced interleukin-1 beta-induced nitrite generation. These findings indicate that ouabain enhances NO synthesis in vascular smooth muscle cells induced by interleukin-1 beta, presumably through an increase in intracellular calcium ion concentrations.
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
July 1995,
European journal of pharmacology,
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
February 1993,
The American journal of physiology,
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
April 1994,
Blood,
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
October 1997,
European journal of pharmacology,
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
February 1996,
European journal of pharmacology,
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
April 2008,
The Journal of pharmacology and experimental therapeutics,
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
July 1993,
Biochemical and biophysical research communications,
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
April 1995,
Hypertension (Dallas, Tex. : 1979),
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
August 1998,
The Kobe journal of medical sciences,
U Ikeda, and
K Furuhashi, and
T Kanbe, and
K Shimada
October 1991,
The Journal of pharmacology and experimental therapeutics,
