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RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities. 1995
M Ubukata, and
N Shiraishi, and
K Kobinata, and
T Kudo, and
I Yamaguchi, and
H Osada, and
Y C Shen, and
K Isono
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Three novel 36-membered macrolide antibiotics, RS-22A, B and C produced by Streptomyces violaceusniger have been isolated. These antibiotics were purified from an acetone extract of the mycelia followed by butanol extraction, centrifugal partition chromatography and HPLC. RS-22A, B, C showed antimicrobial activity against fungi and Gram-positive bacteria.
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