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The value of biotinylated oligonucleotide probes for screening and typing by in situ hybridization of the most frequent genital human papillomavirus infections (HPVs 6, 11, 16, 18, 31, and 33) was assessed. Optimal hybridization conditions were defined on a panel of paraffin-embedded tissue sections previously characterized with HPV full genome probes. Mixtures of oligonucleotides rather than single oligonucleotides were used to improve sensitivity and specificity. All HPV-positive specimens were detected by the screening mixture with a sensitivity and specificity similar to that of full genome probes. Typing mixtures were highly specific for each HPV type. This study confirms the potential of oligonucleotide probes for detecting and typing HPV infections.
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
November 1989,
American journal of clinical pathology,
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
March 1992,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
March 1993,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
January 1990,
Annales de pathologie,
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
January 2001,
Methods in molecular medicine,
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
January 1989,
Annales de pathologie,
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
January 1992,
Cytopathology : official journal of the British Society for Clinical Cytology,
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
January 1994,
Israel journal of medical sciences,
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
October 1997,
BioTechniques,
M L Jourdan, and
M Joannes, and
C Barranger, and
G Sommé, and
A Goudeau
January 1992,
Scandinavian journal of immunology. Supplement,
