-transparent.png){kind=logo}
We measured parathyroid hormone-related protein (PTHrP) in the serum of 15 healthy women within three days of beginning breast-feeding and within one hour of completing nursing. A sensitive immunoradiometric assay that measures N-terminal PTHrP containing at least the first 74 amino acids was used. We found normal PTHrP values in all patients. Values one day before and two days after delivery in a hypoparathyroid woman who chose not to breast-feed were also normal. Since N-terminal PTHrP fragments of 1-36 amino acids or more are biologically active, we believe additional studies using sensitive PTHrP assays that measure smaller fragments and investigations performed under other conditions of breast-feeding are necessary before concluding that PTHrP does not have a role in calcium homeostasis in nursing mothers. Furthermore, additional studies in hypoparathyroid nursing mothers should be performed.
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
November 1992,
Clinical endocrinology,
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
March 1994,
The Journal of clinical endocrinology and metabolism,
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
November 2003,
The Journal of clinical investigation,
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
November 1992,
Clinical endocrinology,
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
March 2008,
The American journal of emergency medicine,
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
April 1995,
European journal of endocrinology,
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
February 1999,
The Journal of clinical endocrinology and metabolism,
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
January 2005,
Acta dermato-venereologica,
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
November 1989,
Rinsho byori. The Japanese journal of clinical pathology,
R H Caplan, and
G G Wickus, and
K Sloane, and
P D Silva
March 1993,
The New England journal of medicine,
