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The human genome contains sequences related to the simian sarcoma-associated virus SSAV. One of these endogenous retroviral elements, S71, is truncated in the pol gene and carries an insertion of a solitary HERV-K LTR. Using a PCR approach we have now identified further S71-related retroviral elements that lack the HERV-K LTR insertion and contain a full-length retroviral reverse transcriptase. Two of these sequences, pCRTK1 and pCRTK6, were cloned and further characterized. Clones pCRTK1 and pCRTK6 showed between 85 and 90% nucleotide homology to each other and to S71 within the "tether" region of the pol gene, indicating that pCRTK1 and pCRTK6 clearly belong to the S71 subgroup of C-type-related human endogenous retroviral elements. Some point mutations inactivating the reverse transcriptase are located at the same positions in pCRTK1 and pCRTK6. Therefore, we assume that these S71-related elements were dispersed in the human genome by reintegration as defective proviruses, probably using enzymes for retrotransposition provided in trans by other retrotransposons or by cellular genes. Examination of the presence of S71-related elements in apes and Old World monkeys revealed that the deletion of reverse transcriptase sequences in S71 has occurred in the lineage of primates prior to the insertion of the HERV-K LTR.
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
December 1996,
Virology,
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
January 1983,
Nature,
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
June 1985,
Journal of virology,
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
March 1989,
Nucleic acids research,
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
August 1981,
Proceedings of the National Academy of Sciences of the United States of America,
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
January 1996,
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association,
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
December 1987,
Journal of virology,
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
August 1982,
Proceedings of the National Academy of Sciences of the United States of America,
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
August 1998,
AIDS research and human retroviruses,
M Haltmeier, and
W Seifarth, and
J Blusch, and
V Erfle, and
R Hehlmann, and
C Leib-Mösch
December 1985,
Biochemical and biophysical research communications,
