Biomaterial Database

The study of pollen and Der p mite-specific IgE antibodies in children with allergic rhinitis. 1995

Y C Wang, and W C Chen

Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan, R.O.C.

The role of pollens and house dust mites in perennial chronic rhinitis has been investigated for the Taipei area. Fifty-four serum specimens were collected from children with chronic rhinitis. EIA kits (Phadezyme RAST) were used to detect specific IgE antibody of nine allergens, including house dust mite (Der p) and eight common pollens. The children were divided into allergic (AR) and nonallergic (NAR) groups, based on the results of skin tests, inhalant allergen-specific IgE screen (Phadiatop), physical examination, past history and family history. The results showed: (1) 41 (76%) patients were defined as allergic rhinitis; (2) Der p specific IgE was detected in 41 (100%) AR patients and 7 (54%) NAR patients (P < 0.005), a strong positive reaction (> 2+) in 83% AR and none NAR patients (P < 0.005); (3) one, or more than one, pollen-specific IgE were found in 13 (32%) AR and 4 (31%) NAR patients. No strong positive reaction was detected in either group. CONCLUSIONS (1) three-fourths of the children with chronic rhinitis are allergic by nature; (2) house dust mite is the major allergen of allergic rhinitis; (3) in the Taipei area, pollen does not play an important role for children with allergic rhinitis.

UI	MeSH Term	Description	Entries
D007073	Immunoglobulin E	An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).	IgE
D008297	Male		Males
D011058	Pollen	The fertilizing element of plants that contains the male GAMETOPHYTES.	Male Gametes, Plant,Male Gametophytes,Microspores, Plant,Plant Microspores,Pollen Grains,Gamete, Plant Male,Gametes, Plant Male,Gametophyte, Male,Gametophytes, Male,Grain, Pollen,Grains, Pollen,Male Gamete, Plant,Male Gametophyte,Microspore, Plant,Plant Male Gamete,Plant Male Gametes,Plant Microspore,Pollen Grain
D011852	Radioallergosorbent Test	An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.	Radioimmunosorbent Assay of Allergens,Allergens Radioimmunosorbent Assay,Allergens Radioimmunosorbent Assays,Radioallergosorbent Tests,Test, Radioallergosorbent,Tests, Radioallergosorbent
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D005260	Female		Females
D006023	Glycoproteins	Conjugated protein-carbohydrate compounds including MUCINS; mucoid, and AMYLOID glycoproteins.	C-Glycosylated Proteins,Glycosylated Protein,Glycosylated Proteins,N-Glycosylated Proteins,O-Glycosylated Proteins,Glycoprotein,Neoglycoproteins,Protein, Glycosylated,Proteins, C-Glycosylated,Proteins, Glycosylated,Proteins, N-Glycosylated,Proteins, O-Glycosylated
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths