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This study describes the carioprotective effect of ceruloplasmin (CAS 9031-37-2) against oxygen free radical injury, as indicated by several biochemical indicators and some cardiodynamic variables. Isolated rat hearts (n = 4-8, p < 0.05, for each experimental point) in Langendorff preparation were exposed to oxygen free radicals generated by electrolysis (10 mA) in the absence and the presence of 0.25 mumol/l purified ceruloplasmin and denaturated ceruloplasmin, in Krebs-Henseleit perfusion solutions. Biochemical indicators (noradrenaline, malondialdehyde, creatine-kinase, lactate dehydrogenase, aspartate aminotransferase, Ca2+ and Mg2+) as well as the electrocardiogram and the left ventricular pressure (LVP), were altered by oxygen free radicals formation, denoting major cellular and tissular damages in the nontreated hearts. Ceruloplasmin exhibited a cardioprotective effect and prevented the oxygen free radical-induced release of noradrenaline, indicating that it can also protect the sympathetic nerve endings from oxygen free-radical injury. Purified ceruloplasmin, a circulating extracellular antioxidant and oxygen free radical scavenger, seems to be an effective heart protective agent against myocardial and neuronal injuries generated by oxygen free radicals.
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
January 1984,
Advances in experimental medicine and biology,
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
January 1987,
Progress in clinical and biological research,
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
June 2012,
Biochemistry and cell biology = Biochimie et biologie cellulaire,
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
January 1986,
Acta physiologica Hungarica,
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
September 1991,
The American journal of medicine,
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
April 1994,
Giornale italiano di cardiologia,
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
April 1986,
Pathology,
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
January 1990,
Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...,
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
March 1994,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
M A Mateescu, and
R Chahine, and
S Roger, and
R Atanasiu, and
N Yamaguchi, and
G Lalumière, and
R Nadeau
January 1982,
Annals of the New York Academy of Sciences,
