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Malignant cells from 52 children with acute lymphocytic leukemia (ALL) were investigated for inactivation of the p15ink4B and p16ink4 genes and other genetic alterations on chromosome 9p21. Homozygous deletions of the p15ink4B and/or the p16ink4 genes were detected in 16 cases and a further 9 cases showed evidence of allelic loss either by hemizygous deletion or loss of heterozygosity (LOH) for 9p21 markers. Most cases had loss of both genes, but 5 patients had lost only p16ink4 and 2 cases had homozygous loss of p15ink4B only. Sequence analysis of all exons of p15ink4B and p16ink4 was performed in patients with hemizygous deletions or LOH for 9p21 markers. A frame shift mutation of p16ink4 exon 1 was shown in 1 case, whereas all other clones carried the wild-type sequence of p15ink4B and p16ink4 in the remaining allele. The data suggest that both the p15ink4B and p16ink4 genes can be inactivated in ALL. The existence of a hitherto undefined tumor-suppressor gene on chromosome 9p cannot be ruled out.
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
October 1996,
Leukemia & lymphoma,
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
September 2007,
American journal of hematology,
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
May 1997,
Gynecologic oncology,
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
May 2009,
Epigenetics,
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
January 1995,
Haematologica,
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
December 1995,
Cancer research,
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
January 1996,
The cancer journal from Scientific American,
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
July 1995,
Cancer research,
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
April 1996,
Nihon rinsho. Japanese journal of clinical medicine,
O Rasool, and
M Heyman, and
L B Brandter, and
Y Liu, and
D Grandér, and
S Söderhäll, and
S Einhorn
September 1997,
The American journal of pathology,
