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In a high endemic fluorosis area in Guizhou, China, 40 human fetuses delivered by induced abortion during the 5th-8th month of gestation were utilized to study dental embryonic samples under transmission electron microscope (TEM). Compared with normal controls, ultrastructure findings in the ameloblast cell organs include swelling of mitochondria, enlargement of SER, increase in RNA granules and RER. This study suggests that the irregularities of the collagenous fibers and crystallites are due to the maldevelopment of the ameloblast Tome's processes, which explains the mechanism of motteled enamel.
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