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Oral submucous fibrosis (OSF) is a high risk precancerous condition, predominantly affecting Indians. Consumption of chilli was hypothesized as an etiologic factor on the basis of ecological observations and a solitary animal experimental study. Subsequent epidemiologic studies that included case-series reports, large cross-sectional surveys, case-control studies, cohort and intervention studies have identified areca nut as the major etiologic agent. Tissue-culture studies involving human fibroblasts, areca nut extracts and areca nut alkaloids supported this etiologic hypothesis by showing fibroblastic proliferation and increased collagen formation. Currently, the role of genetic susceptibility and that of autoimmunity are receiving attention. The influence of nutritional factors, if any, remains unclear.
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
February 2022,
Journal of leukocyte biology,
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
July 2013,
Medical hypotheses,
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
December 2014,
Journal of clinical and experimental dentistry,
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
February 2024,
Journal of oral biosciences,
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
March 2011,
Oral and maxillofacial surgery,
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
January 2006,
Evidence-based dentistry,
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
January 2013,
Dento maxillo facial radiology,
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
September 1996,
Lancet (London, England),
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
January 2002,
Addiction biology,
P R Murti, and
R B Bhonsle, and
P C Gupta, and
D K Daftary, and
J J Pindborg, and
F S Mehta
June 2019,
Periodontology 2000,
