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Two doses of a live, attentuated influenza A/England/42/72 (H3N2) vaccine virus (inhibitor-insensitive Alice strain) were administered intranasally to 130 university students, and placebo was given to 134 students. Fourfold or greater rises in titer of hemagglutination-inhibiting antibody occurred in 68% of all vaccine recipients and in 88% of those with initial titers of less than 1:8; the geometric mean titer of hemagglutination-inhibiting antibody increased from 1:15 to 1:77. A 3.2-fold rise in titer of neuraminidase-inhibiting antibody occurred in 24% of the students. Side effects produced by administration of the vaccine include mild rhinitis and sore throat, which were found only during the first four days after administration of the first dose. Inhibitor-insensitive virus was shed only by three of 31 intensively studied vaccine recipients; these three subjects all had initial serum titers of hemagglutination-inhibiting antibody of less than 1:8. No transmission of vaccine virus to spouses was detected. During a 12-month interval after vaccination, the geometric mean titer of hemagglutination-inhibiting antibody in serum and the prevalence of antibody decreased minimally among the 47 vaccine recipients still available for study.
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
December 1975,
The Journal of infectious diseases,
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
April 2017,
Virology,
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
January 1975,
Canadian journal of public health = Revue canadienne de sante publique,
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
August 1973,
Die Naturwissenschaften,
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
December 1975,
Pediatrics,
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
December 1977,
The Journal of infectious diseases,
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
October 1973,
British medical journal,
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
August 1980,
Lancet (London, England),
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
September 1963,
Sapporo igaku zasshi. The Sapporo medical journal,
R J Rubin, and
G R Noble, and
L Corey, and
W J Brown, and
D Brandling-Bennett, and
H S Kaye, and
M T Coleman, and
M B Gregg, and
W R Dowdle
January 1973,
Japanese journal of microbiology,
