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The effect of morphine-3-glucuronide (M3G) on noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord were assessed by ABC method. It was found that a dose-dependent increase of Fos-like immunoreactive neurons could be induced by M3G intrathecal injection followed by formaline injection into hindpaw. With high dosage M3G (1.1 x 10(-7) mole), dense Fos-like labelling was found in the superficial and the deep dorsal horn bilaterally, While with low dosage M3G (5.4 x 10(-8) and 1.1 x 10(-8) mole), most of the positively labelled neurons were only found in laminae I and II of the ipsilateral dorsal horn to the injured paw. The above results revealed that M3G exerts a potentiating effect on the noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord.
G P Xu, and
Q L Gong, and
L F He
January 1990,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
G P Xu, and
Q L Gong, and
L F He
December 1999,
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G P Xu, and
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G P Xu, and
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G P Xu, and
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January 1992,
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G P Xu, and
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Life sciences,
G P Xu, and
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Pain,
G P Xu, and
Q L Gong, and
L F He
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The Journal of neuroscience : the official journal of the Society for Neuroscience,
G P Xu, and
Q L Gong, and
L F He
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European journal of pharmacology,
G P Xu, and
Q L Gong, and
L F He
November 1992,
The Journal of comparative neurology,
