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Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus. 1995
C K Chu, and
T Ma, and
K Shanmuganathan, and
C Wang, and
Y Xiang, and
S B Pai, and
G Q Yao, and
J P Sommadossi, and
Y C Cheng
Department of Medicinal Chemistry, College of Pharmacy, University of Georgia, Athens 30602, USA.
A novel anti-hepatitis B virus (anti-HBV) agent, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU), was synthesized and found to be a potent anti-HBV and anti-Epstein-Barr virus agent. Its in vitro potency was evaluated in 2.2.15 and H1 cells for anti-HBV and anti-Epstein-Barr virus activities, respectively. In vitro cytotoxicity in MT2, CEM, 2.2.15, and H1 cells was also assessed, and the results indicated high antiviral selectivities of L-FMAU in these cells.
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