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To determine the possible role of the B lymphocyte alloantigen system in renal-transplant rejection, we examined serum specimens from 81 allograft recipients for cytotoxic activity against a panel of normal B lymphocytes. Specimens from 22 of 25 recipients undergoing allograft rejection demonstrated strong B-lymphocyte cytotoxicity whereas only 13 of 56 recipients with normal allograft function showed similar B lymphocyte cytotoxocitiy (P less than 0.0001). In the serum samples of recipients with graft rejection who were followed sequentially, B-lymphocyte cytotoxicity preceded or was concurrent with the onset of functional impairment. The results show that anti-B-lymphocyte antibodies are associated with rejection, but it is quite possible that they are the products of rejection rather than the cause.
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September 1985,
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A J Pennisi, and
C Uittenbogaart, and
R Garrison, and
R N Fine
January 1968,
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September 1975,
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June 2009,
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December 1969,
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A Ting, and
M H Malekzadeh, and
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C Uittenbogaart, and
R Garrison, and
R N Fine
June 2021,
Clinical transplantation,
