Increased axonal regrowth of lesioned rat sciatic nerve by veratrylguanidine methane sulfonate. 1995

U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR 416, Strasbourg, France.

Neurotrophic factors appear as essential factors for normal development and repair of the nervous tissue. Veratrylguanidine methane sulfonate, has been shown to induce important neurite outgrowth of cultured dorsal root ganglia isolated from newborn rats. Its action was similar to that of NGF and was found to be additive to that of NGF. In order to see if this compound was able to stimulate axonal growth in adult animals, we examined the effect of this substance on the regeneration of the lesioned sciatic nerve. Using histochemical, immunohistochemical and ultrastructural studies, it is shown that a single intraperitoneal injection of veratrylguanidine methane sulfonate significantly increases the axonal growth during repair of the adult rat sciatic nerve. The efficiency of this substance is explained by its good targeting and long life time in the sciatic nerve.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D008854 Microscopy, Electron Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen. Electron Microscopy
D009416 Nerve Regeneration Renewal or physiological repair of damaged nerve tissue. Nerve Tissue Regeneration,Nervous Tissue Regeneration,Neural Tissue Regeneration,Nerve Tissue Regenerations,Nervous Tissue Regenerations,Neural Tissue Regenerations,Regeneration, Nerve,Regeneration, Nerve Tissue,Regeneration, Nervous Tissue,Regeneration, Neural Tissue,Tissue Regeneration, Nerve,Tissue Regeneration, Nervous,Tissue Regeneration, Neural
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003714 Denervation The resection or removal of the nerve to an organ or part. Laser Neurectomy,Neurectomy,Peripheral Neurectomy,Radiofrequency Neurotomy,Denervations,Laser Neurectomies,Neurectomies,Neurectomies, Laser,Neurectomies, Peripheral,Neurectomy, Laser,Neurectomy, Peripheral,Neurotomies, Radiofrequency,Neurotomy, Radiofrequency,Peripheral Neurectomies,Radiofrequency Neurotomies
D006146 Guanidines A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
D006651 Histocytochemistry Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods. Cytochemistry
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001369 Axons Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body. Axon

Related Publications

U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
June 2004, Neuroscience letters,
U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
September 1982, Journal of neurobiology,
U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
June 1979, Neuroscience letters,
U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
July 1993, Toxicology and applied pharmacology,
U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
December 1985, Journal of neurochemistry,
U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
May 1981, Neurology,
U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
October 1975, Canadian journal of physiology and pharmacology,
U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
July 1987, Brain research bulletin,
U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
November 1982, Journal of neurosurgery,
U Becherer, and S Kuchler-Bopp, and F Aubert, and B Rousseau, and B M Riederer, and D Renko, and C Quirosa-Guillou, and C Thal, and J P Zanetta
December 1983, Experimental neurology,
Copied contents to your clipboard!