-transparent.png){kind=logo}
Solubilized 125I-omega conotoxin MVIIC receptors from rat cerebellum were immunoprecipitated by antibodies directed against the calcium channel alpha 1A subunit. Anti-alpha 1A antibodies recognized a 240-220, 180 and 160 kDa proteins in immunoblots of cerebellar membranes. Disuccinimidyl suberate cross-linked 125I-omega conotoxin MVIIC to an alpha 2 delta-like 200-180 kDa subunit, which migrated at 150-140 kDa after disulfide reduction. These observations are consistent with a heteromeric structure in which high affinity omega conotoxin MVIIC binding sites formed by alpha 1A subunits are located in close proximity to peripheral alpha 2 subunits.
Related Publications
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
January 1989,
Annals of the New York Academy of Sciences,
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
June 1996,
The Journal of biological chemistry,
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
September 1996,
Muscle & nerve,
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
July 1999,
British journal of pharmacology,
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
April 1996,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
February 1995,
Molecular pharmacology,
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
January 1989,
Annals of the New York Academy of Sciences,
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
January 1999,
Journal of neurology,
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
February 1994,
Neuropharmacology,
N Martin-Moutot, and
C Leveque, and
K Sato, and
R Kato, and
M Takahashi, and
M Seagar
May 1995,
Journal of neurophysiology,
