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Extracellular pH (pHc) was determined by needle microelectrodes in 67 tumour nodules in 58 patients. The objective was to evaluate the relationship between pHe, tumour histology and tumour volume. The mean age of the patients was 62 years, mean depth of the lesions was 2.7 +/- 0.2 cm, and mean tumour volume was 187 +/- 60 cm3. Lesions were located in readily accessible areas such as on the limbs, neck or chest wall. Tumour histologies included: 48% adenocarcinoma; 34% squamous cell carcinoma; 8% soft tissue sarcoma; and 10% malignant melanoma. The mean tumour pHe for the entire group of tumours was 7.06 +/- 0.05 (range 5.66-7.78). Variation in pHe measurements between tumours was greater than the variation in measurements within tumour (F = 7.11, p < 0.01). In adenocarcinomas pHe was 6.93 +/- 0.08 (range 5.66-7.78), in soft tissue sarcomas 7.01 +/- 0.21 (6.25-7.45), in squamous cell carcinomas 7.16 +/- 0.08 (6.2-7.6), and in malignant melanomas 7.36 +/- 0.1 (6.98-7.77). Tumour pHe was significantly different between the four histological groups (p < 0.001). When adenocarcinoma and soft tissue sarcoma lesions were grouped together, pHe was 6.94 +/- 0.08 compared with 7.20 +/- 0.07 in squamous cell carcinomas and malignant melanomas lesions (p < 0.01). Tumour pHe increased as a function of the logarithm of tumour volume at 0.07 +/- 0.02 pH unit/ln cm3 (p = 0.006, r = 0.34). In conclusion, tumour histology and tumour volume were the most important factors determining the range of pHe's.(ABSTRACT TRUNCATED AT 250 WORDS)
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
February 1987,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
August 1966,
Lancet (London, England),
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
September 1985,
International journal of radiation oncology, biology, physics,
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
January 1995,
Acta neurochirurgica,
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
July 1985,
Biochemical pharmacology,
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
January 1991,
Virchows Archiv. B, Cell pathology including molecular pathology,
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
January 1964,
Pathologia et microbiologia,
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
January 1993,
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
August 2004,
Neuropathology and applied neurobiology,
K Engin, and
D B Leeper, and
J R Cater, and
A J Thistlethwaite, and
L Tupchong, and
J D McFarlane
January 1981,
Diagnostic histopathology,
