-transparent.png){kind=logo}
The present study revealed that glucose-induced insulin secretion was significantly inhibited by perfusion with trypsin (10 mug/ml) in the isolated rat pancreas perfusion. However, when trypsin was interposed during perfusion of 16.6 mM glucose, glucose-induced insulin secretion was not suppressed during trypsin infusion. The insulin level was significantly lower in the trypsin treated animals than in the control after completion of trypsin infusion. The results suggest that trypsin does not attack the glucorecoptor bound with glucose but attacks the free glucoreceptor. Interestingly a biphasic pattern of glucose-induced insulin secretion disappeared by the pretreatment with trypsin. The possibility was suggested that tyrpsin prevented the initial binding of glucose to the B-cell.
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
July 1997,
Regulatory peptides,
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
December 1984,
Gastroenterology,
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
November 1988,
European journal of pharmacology,
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
July 1977,
Endocrinology,
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
September 1996,
Acta physiologica Scandinavica,
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
November 1993,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
April 1984,
Life sciences,
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
May 1983,
Archives internationales de pharmacodynamie et de therapie,
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
August 1971,
The Tohoku journal of experimental medicine,
T Toyota, and
K Abe, and
M Kudo, and
Y Goto
January 1988,
Pancreas,
