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Chronic Helicobacter pylori gastritis has been put forward as a risk factor for development of gastric mucosal atrophy and gastric cancer. The purpose of our study was to investigate the long-term effects of H pylori gastritis on the gastric mucosa. We prospectively studied 49 subjects negative for H pylori and 58 positive subjects for a mean follow-up of 11.5 years (range 10-13 years). Serum samples were obtained at the initial and follow-up visits for determination of H pylori IgG antibodies. Gastroscopies with biopsy sampling were done in all patients at both visits. Biopsy specimens were used for assessment of H pylori infection and histology. Development of atrophic gastritis and intestinal metaplasia occurred in 2 (4%) uninfected and 16 (28%) infected subjects. Regression of atrophy was noted in 4 (7%) infected subjects. Development of atrophic gastritis and intestinal metaplasia was significantly associated with H pylori infection (p = 0.0014; odds ratio 9.0, 95% CI 1.9-41.3). The proportion of atrophic gastritis in the study population showed an annual increase of 1.15% (0.5-1.8%). We conclude that H pylori infection is a significant risk factor for development of atrophic gastritis and intestinal metaplasia. Our findings support strongly the causative role of this infection in gastric carcinogenesis.
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
August 1995,
Lancet (London, England),
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
January 1997,
Journal of clinical gastroenterology,
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
April 2002,
Digestive diseases and sciences,
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
January 1997,
Irish journal of medical science,
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
January 2023,
Gut,
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
February 1998,
Alimentary pharmacology & therapeutics,
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
October 2005,
Scandinavian journal of gastroenterology,
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
July 1991,
The British journal of general practice : the journal of the Royal College of General Practitioners,
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
June 1992,
Digestive diseases and sciences,
E J Kuipers, and
A M Uyterlinde, and
A S Peña, and
R Roosendaal, and
G Pals, and
G F Nelis, and
H P Festen, and
S G Meuwissen
April 1997,
Journal of gastroenterology,
