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We report the case of a 3 year old boy who exhibited recurrent serious infections with a transient imbalance of IgG subclass in the second year of life. He suffered from pneumococcal meningitis at 3 months, hepatitis at 9 months, and purulent arthritis at 11 months of age. The second episode of pneumococcal meningitis occurred at 14 months. Serum IgG level was normal for age. Low level of IgG2, undetectable level of IgG4 and negligible level of pneumococcus-specific IgG1-G2 antibodies were found. No other primary immunodeficiency was apparent. Serum IgG2-G4 levels but not pneumococcus-specific IgG1-G2 titers increased by the age of 30 months. At that time, he was inoculated with a polyvalent pneumococcal vaccine along with acellular diphtheria-pertussis-tetanus vaccine. He acquired the immunity against these agents, and had no episodic infections in the following 2 years. This observation stresses the existence of transient IgG subclass deficiency associated with delayed development of the anti-polysaccharide antibody response.
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
April 2020,
Emerging infectious diseases,
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
November 1993,
The Journal of infection,
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
April 1992,
European journal of pediatrics,
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
January 1989,
Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui,
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
January 1991,
The Turkish journal of pediatrics,
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
August 2014,
JPMA. The Journal of the Pakistan Medical Association,
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
August 1998,
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology,
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
November 1988,
Annals of allergy,
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
December 1987,
The Pediatric infectious disease journal,
S Ohga, and
K Okada, and
T Asahi, and
K Ueda, and
Y Sakiyama, and
S Matsumoto
January 1989,
The Journal of the Oklahoma State Medical Association,
