Biomaterial Database

A metabolic complication of severe burns. 1995

A Inglis, and J Hinnie, and J Kinsella

Glasgow Royal Infirmary, UK.

A 32-year-old male was referred to intensive care with possible respiratory sepsis 15 days after sustaining 73 per cent TBSA electrical burns. Investigation revealed previously undiagnosed hyperosmolar non-ketotic diabetic coma. The aetiology, pathogenesis and management of this recognized complication of major burns is discussed. An interesting feature of this case is recovery from 73 per cent burns, severe hyperosmolar non-ketotic diabetic coma and a serum osmolality of 429 mosmol/kg, each of which carry a high mortality probability.

UI	MeSH Term	Description	Entries
D007328	Insulin	A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).	Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008297	Male		Males
D002058	Burns, Electric	Burns produced by contact with electric current or from a sudden discharge of electricity.	Electric Burns,Burn, Electric,Electric Burn
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006944	Hyperglycemic Hyperosmolar Nonketotic Coma	A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.	Coma, Hyperglycemic Hyperosmolar Nonketotic,Hyperosmolar Hyperglycemic Nonketotic Coma,Hyperosmolar Hyperglycemic State,Hyperosmolar Hyperglycemic Syndrome,Hyperosmolar Nonketotic Coma,Nonketotic Hyperglycemic Coma,Nonketotic Hyperosmolar Coma,Coma, Hyperosmolar Nonketotic,Coma, Nonketotic Hyperglycemic,Coma, Nonketotic Hyperosmolar,Comas, Hyperosmolar Nonketotic,Comas, Nonketotic Hyperosmolar,Hyperglycemic Coma, Nonketotic,Hyperglycemic State, Hyperosmolar,Hyperglycemic States, Hyperosmolar,Hyperglycemic Syndrome, Hyperosmolar,Hyperglycemic Syndromes, Hyperosmolar,Hyperosmolar Coma, Nonketotic,Hyperosmolar Comas, Nonketotic,Hyperosmolar Hyperglycemic States,Hyperosmolar Hyperglycemic Syndromes,Hyperosmolar Nonketotic Comas,Nonketotic Coma, Hyperosmolar,Nonketotic Comas, Hyperosmolar,Nonketotic Hyperosmolar Comas,Syndrome, Hyperosmolar Hyperglycemic,Syndromes, Hyperosmolar Hyperglycemic
D000062	Accidents, Occupational	Unforeseen occurrences, especially injuries in the course of work-related activities.	Accidents, Industrial,Industrial Accidents,Occupational Accidents,Accident, Industrial,Accident, Occupational,Industrial Accident,Occupational Accident
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012720	Severity of Illness Index	Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.	Illness Index Severities,Illness Index Severity