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The extent of myocardial accumulation of tocainide, administered as single enantiomers and as well as racemate, was determined in the isolated, spontaneous beating rabbit heart. The heart was retrogradely perfused at a constant rate and fractions of the perfusate were collected during and after infusion. Kinetic parameters for myocardial accumulation and disposition of tocainide were indirectly determined from drug concentration/time course in the outflow perfusate. No stereoselectivity in myocardial accumulation was observed. A two compartment model with mean half-lives for distribution and elimination of 0.60 and 3.78 min, respectively, was fitted to the accumulation and disposition data. At steady-state, tocainide enantiomers were accumulated about three times in the myocardium relative to the perfusion liquid.
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S N Rasmussen
June 1986,
The Journal of pharmacology and experimental therapeutics,
E B Christensen, and
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January 1996,
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E B Christensen, and
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E B Christensen, and
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December 1990,
British journal of pharmacology,
E B Christensen, and
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September 1965,
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E B Christensen, and
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January 1989,
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E B Christensen, and
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April 1987,
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E B Christensen, and
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S N Rasmussen
February 1968,
The Journal of pharmacology and experimental therapeutics,
E B Christensen, and
S H Hansen, and
S N Rasmussen
September 1993,
Anesthesia and analgesia,
E B Christensen, and
S H Hansen, and
S N Rasmussen
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Acta pharmacologica et toxicologica,
