Cytochemical determination of monoamine oxidase activity in lymphocytes and neutrophils of schizophrenic patients. 1995

N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
Department of Pathologic Physiology, University of Athens School of Medicine, Laikon Hospital, Greece.

Monoamine oxidase (MAO) activity was determined cytochemically in peripheral blood lymphocytes and neutrophils of 14 schizophrenic patients and normal controls. The cytochemical method of Glenner modified for smear preparations was utilized. Schizophrenic patients show a tendency to express a lower percentage of MAO-positive neutrophils as compared to the non-schizophrenic controls. This biochemical difference in schizophrenic patients needs further clarification.

UI MeSH Term Description Entries
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008995 Monoamine Oxidase An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4. Amine Oxidase (Flavin-Containing),MAO,MAO-A,MAO-B,Monoamine Oxidase A,Monoamine Oxidase B,Type A Monoamine Oxidase,Type B Monoamine Oxidase,Tyramine Oxidase,MAO A,MAO B,Oxidase, Monoamine,Oxidase, Tyramine
D009504 Neutrophils Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001596 Benzylamines Toluenes in which one hydrogen of the methyl group is substituted by an amino group. Permitted are any substituents on the benzene ring or the amino group. Phenylmethylamine,alpha-Aminotoluene,alpha Aminotoluene
D012559 Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. Dementia Praecox,Schizophrenic Disorders,Disorder, Schizophrenic,Disorders, Schizophrenic,Schizophrenias,Schizophrenic Disorder

Related Publications

N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
May 1977, The American journal of psychiatry,
N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
February 1974, Research communications in chemical pathology and pharmacology,
N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
January 1978, Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
July 1972, Nature,
N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
June 1984, Psychiatry research,
N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
April 1976, The American journal of psychiatry,
N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
November 1979, Psychopharmacology,
N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
January 1978, The American journal of psychiatry,
N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
April 1980, Biological psychiatry,
N Tsavaris, and K Konstantopoulos, and S Vaidakis, and K Koumakis, and G Pangalis
January 1985, Journal of psychiatric research,
Copied contents to your clipboard!