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Cytotoxic effects of lymph and blood components, removed from sheep following renal allografting were determined by in vitro assay using 51Cr labelled donor sheep lymphocytes as target cells. Lytic antibodies were detected in lymph efferent from the node draining the graft site and at lower concentrations in blood serum and in lymph leaving the graft. The cytotoxic antibodies had both complement-dependent and leucocyte-dependent functions; the complement-dependent antibodies were fractionated and shown to be of IgM and IgG1 subclasses. Cytotoxic cells were found in lymph leaving the graft but not in blood or in lymph efferent from the draining node; those detected in the renal lymph were non-specific in action and their appearance correlated with increased numbers of macrophages.
C K Grant, and
E P Adams, and
H R Miller, and
B Morris
August 1976,
American journal of clinical pathology,
C K Grant, and
E P Adams, and
H R Miller, and
B Morris
June 1975,
The New England journal of medicine,
C K Grant, and
E P Adams, and
H R Miller, and
B Morris
January 1969,
Surgical forum,
C K Grant, and
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B Morris
June 1995,
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C K Grant, and
E P Adams, and
H R Miller, and
B Morris
April 1981,
Pathology,
C K Grant, and
E P Adams, and
H R Miller, and
B Morris
July 1977,
Transplantation,
C K Grant, and
E P Adams, and
H R Miller, and
B Morris
March 1976,
Lancet (London, England),
C K Grant, and
E P Adams, and
H R Miller, and
B Morris
May 1975,
Transplantation,
C K Grant, and
E P Adams, and
H R Miller, and
B Morris
March 1971,
Investigative urology,
C K Grant, and
E P Adams, and
H R Miller, and
B Morris
June 1990,
Human cell,
